The Child, Adolescent and Family Branch (CAFB) in the Center for Mental Health Services (CMHS) at the Substance Abuse and Mental Health Services Administration (SAMHSA), U.S. Department of Health and Human Services (HHS), initiated the National Workgroup to address the needs of children and youth who identify as lesbian, gay, bisexual, transgender, questioning, intersex, or two-spirit (LGBTQI2-S) in systems of care (SOC) and their families.